甘草查爾酮A

分析標(biāo)準(zhǔn)品,HPLC≥98%

Licochalcone A

CAS號：58749-22-7

分子式：C21H22O4

分子量：338.4

MDL：MFCD01417903

產(chǎn)品介紹

甘草查爾酮A (Licochalcone A) 是一種黃酮類化合物，具有抗癌功效，對UDP-glucuronosyltransferases (UGTs) 具有廣泛抑制活性。Licochalcone A (LCA) 對 UGT1A1、1A3、1A4、1A6、1A7、1A9 和 2B7 具有強烈的抑制作用 (IC50 和Ki值均低于5 μM)。

熔點：100℃

沸點：532.6℃at760mmHg

外觀：黃色結(jié)晶粉末

溶解性：DMSO  :  ≥  31  mg/mL  (91.61  mM)

儲存條件：2-8℃

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參考文獻(26篇)

26. [IF=3.1] Xiaofei Chen et al."Mechanistic insights into Licorice-Evodiae Fructus interaction: UPLC-MS/MS-based hepatotoxic metabolite detection and CYP3A4 regulation study."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2025 Oct;264:116985

25. [IF=4.8] Zhongyuan Li et al."Combining virus-based affinity ultrafiltration method with serum pharmacochemistry to identify the antiviral pharmacodynamic substances in licorice."JOURNAL OF ETHNOPHARMACOLOGY.2024 Oct;:118978

24. [IF=1.2] Liu Yijie et al."Simultaneous Enrichment and Purification of Licorice Chalcone A and Isoliquiritigenin in Licorice Using a Mixed-Mode Monolith."CHROMATOGRAPHIA.2024 Oct;:1-11

23. [IF=6.7] Yushu Wang et al."Honey-fried licorice in the treatment of arrhythmia: structure elucidation and the mechanism of antiarrhythmic activity."PHYTOMEDICINE.2024 Nov;:156259

22. [IF=4.1] Yingying Zhang et al."Licochalcone A: A promising antiparasitic drug against giardiasis."International Journal for Parasitology-Drugs and Drug Resistance.2024 Dec;:100573

21. [IF=3.4] Zhijuan Tang et al."Neuroprotective effect of Licochalcone A against aluminum chloride-induced neurotoxicity by reducing Aβ accumulation, oxidative stress and inflammatory reaction."NEUROTOXICOLOGY.2025 May;108:295

20. [IF=3.4] Han Yuxuan et al."Physicochemical parameters combined with sensory and discriminant regression, for quality and sensory characterization of licorice for both food and medicine."Journal of Food Measurement and Characterization".2024 Mar;:1-10

19. [IF=5.4] Xinxin Wu et al."The therapeutic efficacy and mechanism action of Si Cao formula in the treatment of psoriasis: A pilot clinical investigation and animal validation."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117662

18. [IF=7.2] Doudou Wang et al."Licochalcone A alleviates abnormal glucolipid metabolism and restores energy homeostasis in diet-induced diabetic mice."PHYTOTHERAPY RESEARCH.2023 Oct;:

17. [IF=12.7] Zhongyuan Li et al."Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage."JOURNAL OF MEDICAL VIROLOGY.2023 Aug;95(8):e29059

16. [IF=5.56] Liu Zidi et al."Abiotic factors and endophytes co-regulate flavone and terpenoid glycoside metabolism in Glycyrrhiza uralensis."APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.2023 Mar;:1-18

15. [IF=3.776] Yu-Feng Huang et al."Simultaneous determination of twenty-nine active compounds in fuzhengjiedu granules by HPLC-QQQ-MS/MS."Heliyon.2023 Feb 11;9(2):e13675

14. [IF=4.927] Qinhua Zheng et al."Protective Effect of Flavonoids from Mulberry Leaf on AAPH-Induced Oxidative Damage in Sheep Erythrocytes."MOLECULES.2022 Jan;27(21):7625

13. [IF=5.988] Jun Li et al."Screening of anti-heart failure active compounds from fangjihuangqi decoction in verapamil-induced zebrafish model by anti-heart failure index approach.."Frontiers in Pharmacology.2022 Oct;13:999950-999950

12. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199

11. [IF=1.978] Chen Ming-jun et al."Composite Sophora Colon-Soluble Capsule Ameliorates DSS-Induced Ulcerative Colitis in Mice via Gut Microbiota-Derived Butyric Acid and NCR+ ILC3."Chin J Integr Med. 2022 Apr;:1-10

10. [IF=6.244] Yalei Wang et al."Exploration of the Potential Mechanism of Qi Yin San Liang San Decoction in the Treatment of EGFRI-Related Adverse Skin Reactions Using Network Pharmacology and In Vitro Experiments.."Front Oncol. 2022 Mar;12:790713-790713

9. [IF=5.545] Yuxuan Han et al."Multi-dimensional "projection" - the impact of abiotic stresses on the content of seven active compounds and expression of related genes in Glycyrrhiza uralensis Fisch."Environ Exp Bot. 2022 May;197:104846

8. [IF=2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC Fingerprint."Evid-Based Compl Alt. 2021;2021:8834826

7. [IF=4.451] Zijian Wang et al."Licorice flavonoids nanoparticles prepared by liquid antisolvent re-crystallization exhibit higher oral bioavailability and antioxidant activity in rat."J Funct Foods. 2019 Jun;57:190

6. [IF=4.769] Zhenzhong Yang et al."Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe."J Pharm Anal. 2020 Nov;:

5. [IF=2.896] Tian-Ming Wang et al."Simultaneous determination of 14 major components in Longhu Rendan pills by ultra-high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry."Anal Methods-Uk. 2014 Apr;6(9):2923-2929

4.  Tian D-D, Wang W, Wang H-N, Sze SCW, Zhang Z-J. Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats. Molecules. 2016; 21(6):696. https:##doi.org/10.3390/molecules

3.  Yang, Zhenzhong, et al. "Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe." Journal of Pharmaceutical Analysis (2020).https:##doi.org/10.1016/

2.  郭婉怡,袁蓓,汪倩,蘇曉慧.甘草查爾酮A通過調(diào)控MAPK信號通路抑制MH7A細(xì)胞增殖并誘導(dǎo)凋亡[J].中國實驗方劑學(xué)雜志,2020,26(24):68-74.

1.  王梨明, 范志浩, 范曉麗,等. 甘草查爾酮A對人骨肉瘤細(xì)胞增殖、凋亡的影響及其機制[J]. 廣西醫(yī)學(xué), 2019, 41(012):1528-1531.