鬼臼毒素

分析標準品,HPLC≥98%

Podophyllotoxin

CAS號：518-28-5

分子式：C22H22O8

分子量：414.41

MDL：MFCD00075290

產品介紹

Podofilox (Podophyllotoxin) 是微管組裝和DNA拓撲異構酶II抑制劑。

熔點：183-184℃(lit.)

沸點：597.9℃ at 760 mmHg

比旋光度：-110.7 o (C=1, CHCL3)

外觀：白色針狀結晶粉末

溶解性：DMSO  :  100  mg/mL  (241.31  mM;  Need  ultrasonic)

儲存條件：2-8℃

注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(16篇)

16. [IF=4.5] Lei Chen et al."Self-assembled ROS -responsive podollyllotoxin twin drug nanoparticles for enhanced anticancer therapy."JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2025 Mar;105:106650

15. [IF=13.3] Chaozheng Zhang et al."Dual targeting of FR+CD44 overexpressing tumors by self-assembled nanoparticles quantitatively conjugating folic acid-hyaluronic acid to the GSH-sensitively modified podophyllotoxin."CHEMICAL ENGINEERING JOURNAL.2025 Feb;505:159276

14. [IF=3.7] Min Wang et al."Characterizing the impact of podophyllotoxin on pulmonary toxicity and gut-lung microbiota interactions in SD rats based on TEC concept."Microbiology Spectrum.

13. [IF=4.4] Ma Kaiyue et al."Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept."Frontiers in Pharmacology.2024 Sep;15:

12. [IF=5.6] Shengnan Xu et al."Effects of age and tissue of Juniperus sabina L. on its phytochemical characteristics, anti-cholinesterase, antidiabetes, and anti-drug resistant bacteria activities."Frontiers in Plant Science.10.3389/fpls.2023.1174922

11. [IF=5.1] Hongyan Lin et al."Modified Podophyllotoxin Phenoxyacetamide Phenylacetate Derivatives: Tubulin/AKT1 Dual-Targeting and Potential Anticancer Agents for Human NSCLC."JOURNAL OF NATURAL PRODUCTS.2023;XXXX(XXX):XXX-XXX

10. [IF=4.103] Yingyu Ma et al."Redox-responsive self-assembled podophyllotoxin twin drug nanoparticles for enhanced intracellular drug delivery."Biomedical Materials.2023 May;18(4):045019

9. [IF=4.384] Xiu Zhao et al."Preparation, characterization and biological evaluation of β-cyclodextrin-biotin conjugate based podophyllotoxin complex."Eur J Pharm Sci. 2021 May;160:105745

8. [IF=5.221] Zi  Cheng-Ting et al."Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents."Front Chem. 2019 Jun;0:434

7. [IF=3.641] Cheng-Ting Zi et al."Synthesis and antitumor activity of novel per-butyrylated glycosides of podophyllotoxin and its derivatives."Bioorgan Med Chem. 2015 Apr;23:1437

6. [IF=5.64] Wu  Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466

5.  Zi, Cheng-Ting, et al. "Synthesis and Anticancer Activity of 4 β-Triazole-podophyllotoxin Glycosides." Natural products and bioprospecting 5.2 (2015): 83-90.

4.  范素芳, 馬俊美, 劉茁,等. 高效液相色譜-串聯質譜測定食品中15種有毒生物堿[J]. 食品科學, 2018, 39(22):290-295.

3.  董玉鵬 孫萍 李永才 畢陽 張苗 黃怡 張婷婷.反式-2-己烯醛對梨果黑斑病菌Alternaria alternata的抑菌作用及其機理[J].食品科學 2020 41(07):191-197.

2.  山金鳳, 劉寧芝, 杜欣韻,等. 鬼臼甘草配伍有效成分提取工藝的研究[J]. 現代化工, 2016(12):47-50.

1.  王萍  陳濤  劉永玲 等. 響應面法優化桃兒七中鬼臼毒素的熱回流提取工藝[J]. 中藥材  2012  35(011):1864-1867.