荷葉堿

分析標準品,HPLC≥98%

Nuciferine

CAS號：475-83-2

分子式：C19H21NO2

分子量：295.376

MDL：MFCD01664592

產品介紹

藥理藥效：具有減肥降脂的作用。

熔點：165.5℃

沸點：430.7℃at760mmHg

比旋光度：(c, 1 in EtOH)-164

外觀：白色粉末

溶解性：DMSO：3mg/ml

儲存條件：2-8℃

注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(45篇)

45. [IF=4.9] Lalai Zikela et al."Effects and Mechanisms of Nuciferine on Constipation through Regulation of the SCF/c-Kit/NF-κB/TLR4 Signaling Pathway in STC Model Mice."JOURNAL OF NUTRITIONAL BIOCHEMISTRY.2025 Jul;:110045

44. [IF=6.3] Shengnan Zhu et al."Nuciferine Exerts Anti-Inflammatory Effects in Mice With Non-Alcoholic Steatohepatitis by Regulating the miR-23a-3p-SIRT1-NF-κB Pathway and Akkermansia muciniphila-Extracellular Vesicles."PHYTOTHERAPY RESEARCH.2025 Jul;:

43. [IF=3.5] Zhiqiang Zhao et al."Nuciferine alleviates non-alcoholic steatohepatitis by restoring endoplasmic reticulum stress."EXPERIMENTAL CELL RESEARCH.2025 Jun;449:114599

42. [IF=5.7] Sha Chen et al."Characterization and Molecular Engineering of a N-Methyltransferase from Edible Nelumbo nucifera Leaves Involved in Nuciferine Biosynthesis."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2024;72(41):22926–22938

41. [IF=2.8] Kun Yang et al."Rutin Ameliorates BHBA-Induced Inflammation and Lipid Accumulation in Calf Hepatocytes Through NF-κB Signaling Pathway."CURRENT ISSUES IN MOLECULAR BIOLOGY.2025 Apr;47(4):274

40. [IF=4.6] Hao WANG et al."Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance."Chinese Journal of Natural Medicines".2024 Ap

39. [IF=9.9] Xiangyang Zhu et al."Neuroprotective effects of nuciferine on high-fat diet-induced cognitive dysfunction in obese mice: Role of insulin resistance, neuroinflammation, and oxidative stress."Food Frontiers".2024 Feb;:

38. [IF=8.4] Yanzhao Liu et al."Enzyme-Assisted Extraction of Nuciferine and Quercetin from Lotus Leaves Using the Aqueous-Based Method: A Sustainable Approach."ACS Sustainable Chemistry & Engineering.2023;11(50):17687–17696

37. [IF=6] Jiahuan Xu et al."A new strategy for the preparation of nuciferine from lotus leaf via expanded bed adsorption extraction integrated with pH dependent liquid-liquid extraction and cooling crystallization."Sustainable Chemistry and Pharmacy.2024 Feb;37:1014

36. [IF=3.5] Zhiyuan Fang et al."Nuciferine protects bovine hepatocytes against free fatty acid-induced oxidative damage by activating the transcription factor EB/peroxisome proliferator-activated receptor γ coactivator 1 alpha pathway."JOURNAL OF DAIRY SCIENCE.10.3168

35. [IF=5.464] Jiahuan Xu et al."D-limonene as an alternative for the extraction and purification of nuciferine from lotus leaf via multi-stage vortex assisted two-phase solvent extraction integrated with solid phase extraction using mesoporous material SBA-15 as adsorb

34. [IF=2.215] Qin Li et al."Valorization of lotus leaf by in-situ expanded bed adsorption and ultrasonic assisted desorption."CHEMICAL ENGINEERING & TECHNOLOGY.2022 Dec;:

33. [IF=5.895] Jinxia Li et al."Nuciferine Ameliorates Nonesterified Fatty Acid-Induced Bovine Mammary Epithelial Cell Lipid Accumulation, Apoptosis, and Impaired Migration via Activating LKB1/AMPK Signaling Pathway."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2022;XXXX(

32. [IF=7.291] Yu Yuetong et al."Functional characterization and key residues engineering of a regio-promiscuity O-methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in Nelumbo nucifera."Horticulture Research.2022 Dec;:

31. [IF=3.2] Chenyang Hao et al."Nontarget Metabolites of Rhizomes of Edible Sacred Lotus Provide New Insights into Rhizome Browning."JOURNAL OF FOOD QUALITY.2022 Oct 26;2022:3943052

30. [IF=0] Danni Wang et al."Identification of Q-Markers from Hedan Tablet by employing “spider-web" mode and taking compounds’ hepatotoxicity into account."Chinese Herbal Medicines.2022 Aug;:

29. [IF=4.212] Chang Chen et al."Nuciferine attenuates acute ischemic stroke in a rat model: a metabolomic approach for the mechanistic study."Molecular Omics.2022 Jul;:

28. [IF=5.307] Yu-kai Zhang et al."Synthesis and bioactivity evaluation of novel nuciferine derivatives with antihyperuricemia and nephroprotective effects."BIOORGANIC CHEMISTRY.2022 Sep;126:105916

27. [IF=7.491] Yeqing Ruan et al."Processing tactics for low-cost production of pure nuciferine from lotus leaf."ULTRASONICS SONOCHEMISTRY. 2022 May;86:106026

26. [IF=3.394] Chang Chen et al."Protective Effects of Nuciferine in Middle Cerebral Artery Occlusion Rats Based on Transcriptomics."Brain Sciences. 2022 May;12(5):572

25. [IF=11.413] Xiliang Du et al."Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway."Acta Pharm Sin B. 2021 Dec;:

24. [IF=1.902] Yongjing Liu et al."Evaluation of Green and Efficient deep eutectic solvents as media for extracting Alkaloids from Lotus Leaf."Biomedical Chromatography. 2021 Dec 06

23. [IF=7.514] YueTong Yu et al."Identification and Quantification of Oligomeric Proanthocyanidins, Alkaloids, and Flavonoids in Lotus Seeds: A Potentially Rich Source of Bioactive Compounds."Food Chem. 2022 Jan;:132124

22. [IF=3.373] Na Zhang et al."TLC–MS identification of alkaloids in Leonuri Herba and Leonuri Fructus aided by a newly developed universal derivatisation reagent optimised by the response surface method."Phytochem Analysis. 2021 May;32(3):242-251

21. [IF=3.935] Peiliang Zhang et al."TLC-electrostatic field induced spray ionization-MS analysis of diverse structural skeletons and its coupling with TLC bioautography for characterization of lipase inhibitory components in American ginseng."J Pharmaceut Biomed. 2019

20. [IF=4.451] Haiyan Wen et al."Nuciferine attenuates the progression of osteoarthritis by targeting PI3K/Akt/NF-κB signaling pathway."J Funct Foods. 2021 Nov;86:104682

19. [IF=5.396] Zhen Shi et al."Nuciferine improves high-fat diet-induced obesity via reducing intestinal permeability by increasing autophagy and remodeling the gut microbiota."Food Funct. 2021 Jul;12(13):5850-5861

18. [IF=3] Zhang  Pengyu et al."Discovery of novel antagonists on β2-adrenoceptor from natural products using a label-free cell phenotypic assay."N-S Arch Pharmacol. 2018 Dec;391(12):1411-1420

17. [IF=3.174] Chen  Xingxing et al."Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway."Inflamm Res. 2018 Dec;67(11):903-911

16. [IF=3.225] Fugang  Wang et al."Pharmacokinetics, tissue distribution, bioavailability, and excretion of nuciferine, an alkaloid from lotus, in rats by LC/MS/MS."Drug Dev Ind Pharm. 2018;44(9):1557-1562

15. [IF=3.512] Thitirat Meelaph et al."Coregulation of Biosynthetic Genes and Transcription Factors for Aporphine-Type Alkaloid Production in Wounded Lotus Provides Insight into the Biosynthetic Pathway of Nuciferine."Acs Omega. 2018;3(8):8794–8802

14. [IF=5.279] Xianbao Deng et al."Analysis of Isoquinoline Alkaloid Composition and Wound-Induced Variation in Nelumbo Using HPLC-MS/MS."J Agr Food Chem. 2016;64(5):1130–1136

13. [IF=6.558] Lei Zhang et al."Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves."Anal Chim Acta. 2017 May;967:52

12.  Zhang, Lei, et al. "Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves." Analytica chimica acta 967 (2017): 5

11.  Zhang, Lei, et al. "Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves." Analytica chimica acta 967 (2017): 5

10.  Chen, X., Zheng, X., Zhang, M. et al. Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway. Inflamm. Res. 67, 903–911 (2018). https:##doi.org/10.1007/s00011-018-1183-2

9.  Fugang Wang, Juan Cao, Xueqin Hou, Zhiyong Li & Xiaolan Qu (2018) Pharmacokinetics, tissue distribution, bioavailability, and excretion of nuciferine, an alkaloid from lotus, in rats by LC/MS/MS, Drug Development and Industrial Pharmacy, 44:9, 1557-1562, D

8.  鄭艷艷,李莉,袁曉慶,孔方,劉言娟.響應面法優化蝸牛酶輔助超聲提取荷葉總生物堿的工藝研究[J].安徽農業科學,2020,48(21):183-187.

7.  陳強,張華,沙玫,劉永靜.一測多評法同時測定荷葉中4種生物堿含量[J].福建中醫藥,2020,51(06):29-32.

6.  尹秀文, 侯成波, 陳江鵬,等. 采用在體單向腸灌流模型研究荷葉多成分整體的腸滲透性[J]. 中國中藥雜志, 2017, 42(008):1525-1531.

5.  李帆. 荷葉堿在青霉菌培養基中抑菌效果的研究[J]. 生物化工, 2018, 4(06):99-101.

4.  侯成波, 董月柳, 尹秀文,等. 荷葉多成分整體的腸滲透性研究[J]. 中國中藥雜志, 2016, 41(07):1183-1187.

3.  吳鵬,李慧芬,張學蘭,崔偉亮,王均秀.炒炭對荷葉主要化學成分轉化機制的研究[J].中成藥,2015,37(08):1767-1770.

2.  李夢杰  劉蘇珍  周斌 等. RP-HPLC法同時測定荷葉顆粒中3種有效成分的含量[J]. 中國藥房  2016(18期):2532-2534.

1.  夢杰 劉蘇珍 周斌 崔小弟 陳振華.HPLC法同時測定荷葉中的荷葉堿、蘆丁、槲皮素[J].中成藥 2016 38(01):111-114.

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